Lymphoma, Mantle Cell

Mantle Cell lymphoma (MCL) is one of about 30 sub-types of Non-Hodgkin Lymphoma. MCL represents up to 8% of all diagnosed lymphomas. It is a cancer of the B-lymphocyte. Most patients who have MCL are 60 years old or greater and more commonly male than female. Many patients are diagnosed with swollen lymph nodes in the neck, armpit, or groin, or an enlarged spleen, which may cause fullness under the left rib cage or abdominal pain.

The cause(s) of MCL are unknown. The stage of MCL can vary at diagnosis and throughout treatment. Stages of MCL include stage I, II, III, or IV. Although therapies are usually given with curative intent, many times the lymphoma returns within 1 – 2 years. Stem cell transplant and combined, multi-drug therapies are usually more effective than single medications.

Medications for MCL may include intravenous infusions, oral tablets or capsules, or a combination of IV and oral medications. Patients may be diagnosed with MCL without having any symptoms. Others may go to their doctor with symptoms of swollen lymph nodes, a large spleen, or decreased appetite. The effectiveness of the treatment may depend upon the stage at diagnosis.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Notice to user: The term chemotherapy, later shortened to “chemo”, originated in the early 1900s from Nobel Prize winning German physician and chemist, Dr. Paul Erlich. Dr. Erlich defined chemotherapy to mean “the use of chemicals as a therapy to treat disease.” (Source). Many years later, the term became synonymous with the use of chemicals to treat cancer specifically. Because early cancer therapies became quickly known for their severe side effect profile, the term chemotherapy took on a negative connotation. If we fast forward several decades, the anti-cancer therapies used today have become refined, and for many diseases, treatment can be safely taken in the comfort of your own home.

As chemotherapy has become particularly targeted, certain side effects have lessened, while new side effects have emerged. However, the premise behind therapy, that is using a chemical to kill cancer, has not changed. Therefore, the clinicians who created ChemoExperts.com believe the term “chemotherapy” still very much applies to all anti-cancer medications, but importantly, can no longer suggest what, if any, side effects a patient is likely to experience. For this to become clear, education regarding each individual drug, as well as information derived from the use of combination therapy (multiple chemo medications) is required. As a result, we have structured our website to make it easier for users to learn about cancer treatment and hope that if you are taking or receiving chemotherapy, that ChemoExperts.com is able to provide you with the tools needed to make the journey a little easier and life more rewarding.

Treatment Options

References

Wang Y, Ma S. Risk factors for etiology and prognosis of mantle cell lymphoma. Expert Rev Hematol. 2014;7:233-243.