Polycythemia Vera

Polycythemia refers to an increased production of red blood cells. There can be many causes of this, including smoking, sleep apnea, or living at high altitudes.

Polycythemia Vera, or "P. Vera", also causes increased red blood cell production, and is almost always the result of a gene mutation known as "JAK2V617F."

P. Vera may increase the risk of a blood clot, such as a heart attack or stroke. Very rarely, it may transform into another disease such as myelofibrosis or acute myeloid leukemia, however this often takes several decades.

Peginterferon alfa-2a (Pegasys®) and ruxolitinib (Jakafi®) are common treatments for polycythemia vera. Please click on the treatment options below to learn more.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Notice to user: The term chemotherapy, later shortened to “chemo”, originated in the early 1900s from Nobel Prize winning German physician and chemist, Dr. Paul Erlich. Dr. Erlich defined chemotherapy to mean “the use of chemicals as a therapy to treat disease.” (Source). Many years later, the term became synonymous with the use of chemicals to treat cancer specifically. Because early cancer therapies became quickly known for their severe side effect profile, the term chemotherapy took on a negative connotation. If we fast forward several decades, the anti-cancer therapies used today have become refined, and for many diseases, treatment can be safely taken in the comfort of your own home.

As chemotherapy has become particularly targeted, certain side effects have lessened, while new side effects have emerged. However, the premise behind therapy, that is using a chemical to kill cancer, has not changed. Therefore, the clinicians who created ChemoExperts.com believe the term “chemotherapy” still very much applies to all anti-cancer medications, but importantly, can no longer suggest what, if any, side effects a patient is likely to experience. For this to become clear, education regarding each individual drug, as well as information derived from the use of combination therapy (multiple chemo medications) is required. As a result, we have structured our website to make it easier for users to learn about cancer treatment and hope that if you are taking or receiving chemotherapy, that ChemoExperts.com is able to provide you with the tools needed to make the journey a little easier and life more rewarding.

Treatment Options

Created: May 22, 2016 Updated: August 7, 2018

References

1) Kiladjian JJ, Cassinat B, Chevret S, et al. Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. Blood. 2008;112:3065-3072.

2) Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372:426-435.